Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Inclusion Criteria: * Subject must be between the ages of 18 and 80, inclusive * Subject must have a diagnosis of prosthetic joint infection (PJI) in a hip or knee joint which has never previously been totally revised because of an infection and for which they are anticipated to undergo a two-stage replacement surgery * Subject must have a positive microbiological identifier of staphylococci. * If Subject is female of childbearing potential, must be willing to practice reliable birth control Exclusion Criteria: * Subject has permanent intravascular prosthetic material such as heart valves or pacemakers * Subject has a creatinine clearance (CLCR) \<30 mL/min as determined by the Cockcroft-Gault equation using actual body weight. * Subject has significant hepatic dysfunction * Subject has a fungal or mycobacterial PJI * Subject is known to be HIV-infected with CD4 count ≤ 200 cells/ mm3 * Subject has an abnormal creatine phosphokinase (CPK) (elevated CPK level ≥ 2x ULN) at baseline as measured by central laboratory * Subject is currently under treatment with chemotherapeutic agents excluding chronic maintenance therapy (e.g. tamoxifen to prevent relapse of primary breast cancer) * Subject is pregnant, nursing, or lactating. * Subject is receiving or is expected to receive chronic immunosuppressive therapy during the study.