CompletedNot Applicable

Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

United States24 participantsStarted 2006-12

Plain-language summary

This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge. Ten vasomotor rhinitis (VMR) patients with nasal symptoms triggered predominantly by cold air, four VMR patients with symptoms triggered predominantly by chemicals, and ten nonallergic, non-rhinitic control subjects will be studied.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Changes in temperature and/or humidity predominantly ("physical triggers"; n = 10); or
✓. Two or more nonspecific irritant triggers predominantly, including: perfumes or colognes,cleaning products, environmental tobacco smoke, vehicular exhaust, paint odors, etc. ("irritant triggers";n = 4). This history shall be of at least two years' duration.

What they're measuring

Net Proportional Change in Nasal Airway Resistance

Timeframe: One hour

Trial details

NCT IDNCT00415493

SponsorAssociated Scientists to Help Minimize Allergies

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2007-10

Results submitted2012-07-20

View on ClinicalTrials.gov More Vasomotor Rhinitis trials