Functional Magnetic Resonance Imaging - Synthetic Aperture Magnetometry (fMRI-SAM) and Alzheimer'… (NCT00412048) | Clinical Trial Compass
WithdrawnNot Applicable
Functional Magnetic Resonance Imaging - Synthetic Aperture Magnetometry (fMRI-SAM) and Alzheimer's Disease
0Started 2012-04
Plain-language summary
The aim of the protocol is to study the resting brain activation profile of 3 groups of people, using a new fMRI procedure, called fMRI-SAM. fMRI-SAM will be applied to 25 Alzheimer's disease (AD) patients, 25 patients suffering from amnestic - mild cognitive impairment (MCI) - a clinical picture which may be a prodromal form of AD - and 60 healthy controls. The first analysis of the data will search differences of brain activation profiles between the 3 groups. In the second step, the investigators will study the predictive value of fMRI-SAM to detect MCI patients who will later convert to AD.
Who can participate
Age range
55 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria:
* Alzheimer's disease of mild to moderate severity (25 patients)
* Amnestic MCI patients (25 patients)
* 55-75 year-old patients
Exclusion criteria:
* Any other cause of dementia for AD patients
* Any stroke
* Any disease with a negative vital prognosis
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was withdrawn before enrolling anyone — do you know why it was withdrawn, and does that affect whether the imaging approach it was studying, combining fMRI with SAM, is still being used or tested elsewhere?
2Since this study was comparing brain imaging results between people with mild cognitive impairment, Alzheimer's disease, and healthy subjects, would having this kind of specialized brain scan actually change my diagnosis or treatment plan in any way?
3Because this trial never got off the ground, there's no safety or outcome data from it — are there similar completed studies using fMRI or magnetometry in Alzheimer's patients that you could point me to so we can understand what the research actually found?
4Given that this was listed as Phase NA, meaning it was more of an observational imaging study than a treatment trial, is participating in brain imaging research like this something that could benefit my care directly, or would it mainly help future patients?
5Are there currently active studies looking at brain imaging biomarkers for Alzheimer's or mild cognitive impairment that might be worth discussing as an alternative to this withdrawn trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Comparing fMRI data between 3 groups of subjects: MCI, Alzheimer's disease and normal subjects