Evaluate the Safety and Efficacy of a 5-HT4 Agonist in Chronic Constipation (ACCORD Trial) (NCT00391820) | Clinical Trial Compass
CompletedPhase 2
Evaluate the Safety and Efficacy of a 5-HT4 Agonist in Chronic Constipation (ACCORD Trial)
United States360 participantsStarted 2006-10
Plain-language summary
Study 0038 compares the safety and effectiveness of an investigational drug, TD-5108 with placebo (a sugar pill) for the treatment of chronic constipation.
Who can participate
Age range
18 Years – 64 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This is a Phase 2 trial for a 5-HT4 agonist in chronic constipation — what does it mean that it's Phase 2, and how much do we actually know so far about whether this type of drug is safe and effective?
2Since the ACCORD trial has already been completed, has my doctor seen or reviewed any of the results, and do those findings change how they'd think about this approach for my specific situation?
3The trial measured 'clinical response' as its main outcome — how was that defined, and is that the kind of improvement that would actually matter to me day-to-day?
45-HT4 agonists work on serotonin receptors in the gut — are there any known risks or side effects with this class of drug that I should weigh against my current symptoms before considering anything like this?
5Before looking at a completed Phase 2 trial, are there standard treatments or newer approved options I should try first, or does my doctor think the approach studied here would be a better fit for my case?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.