Sedating Antidepressant Improves Driving Safety in Patients With Major Depressive Disorder

Inclusion Criteria: * Fulfilling DSM-IV criteria for Major Depressive Disorder * Score of Hamilton Rating Scale for Depression (HDRS-17) \> 17 * Patient to be prescribed mirtazapine (Remeron) as determined by physician * Subject has no known clinically significant abnormal vital signs or other clinical findings at screening. * Patients should have a driving license for more than 3 years and drive over 15,000 km year. * Females of childbearing potential must willingly use effective birth control. Exclusion Criteria: * Night shift workers. * A history or present condition of: Bipolar Disorder or Depressive Disorder not Otherwise Specified,Schizophrenia or other psychotic disorders (according to DSM-IV), Schizotypal or Borderline personality disorder, Organic mental disorders * A present condition of: Anxiety Disorders (according to DSM-IV), Eating Disorders, Postpartum Depression * Epilepsy or a history of seizure disorder or ever received treatment with anticonvulsant medication for epilepsy or seizures * PSG recording of an extremely abnormal sleep EEG (other than that which would be expected with depression) * Alcohol or substance abuse (according to DSM-IV) during the last 6months prior to baseline. * Any physical disease, which may explain the symptoms of depression. * Any chronic physical disease, which is not stabilized.