TNF-alpha is the main cytokine implicated in the formation of lumbar spinal fibrosis. Inhibiting TNF-alpha could significantly decrease spinal fibrosis after lumbar discectomy.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* age over 18 years old
* sciatica post discectomy
* Pain with VAS \> 40 mm and impossibility to have his usual activity
* Surgical discectomy (less than 2 years and more than 6 months)
* Painless of more than one month and less than one year after the discectomy
* MRI with gadolinium injection of less than 6 months and done more than 6 months after the discectomy
* Presence of spinal fibrosis on MRI (hyposignal in T1 enhanced by gadolinium and hypersignal in T2)
* failure of epidural injection treatment
* absence of tuberculosis
* contraception for woman
* informed consent
Exclusion Criteria:
* Chronic psychiatric pathologies not treated
* Presence of conflict between nerve root and herniated disc or disc fragments or spinal stenosis
* severe cognitives troubles
* severe cardiac failure (class III or IV)
* Tuberculosis (active or latent), severe infections
* Cancers
* Allergy reactions to the drug studied
* Difficulties to understand french
* Patients enrolled in another clinical trial in the past three months
* pregnancy, breastfeeding or no contraception