A Research Study of V3381 for the Treatment of Diabetic Peripheral Neuropathic Pain

Inclusion Criteria: * Males or females 18-75 years of age * Diabetes mellitus (type I or type II) * No change in medications for reducing blood sugar within 4 weeks before screening * Experiencing daily pain due to diabetic neuropathy for at least 6 months but not more than 5 years * Neuropathic pain must begin in the feet, with relatively symmetrical onset. * Willing to perform self-monitoring of blood glucose * Able to communicate intelligibly with the investigator and study coordinator * Keeping all appointments for clinic visits, tests, and procedures Exclusion Criteria: * Any clinically significant neurologic disorders (with the exception of diabetic peripheral neuropathic pain) * Any clinically significant or unstable medical or psychiatric condition that would interfere with the patient's ability to participate in the study * Prior renal transplant or current renal dialysis * Pernicious anemia * Untreated hypothyroidism * Amputations due to diabetes mellitus (with the exception of toes) * Any clinically significant abnormal electrocardiogram (ECG) * Any history of cardiac arrhythmia * History of myocardial infarction * Active angina * Uncontrolled hypertension (i.e., \> 140/90 mm Hg) * Known or at high risk of hepatitis B or C infection * Known or at high risk of human immunodeficiency virus (HIV) infection * Any anticipated need for surgery during the study * Glycosylated hemoglobin (HbA1c) \> 9% * Known seizure disorder * Any malignancy in the past 2 years (with t…