Effect of Samarium on the Relief of Pain Due to Vertebral Metastases

Inclusion Criteria: * The patient must be 18 years of age or older * The patient must have histologically proven malignancy in the primary site (breast, prostate, or lung) * The patient must have a radiographic evidence of bone metastasis, and this must have been performed within 8 weeks prior to enrollment in the study. Acceptable studies include plain radiographs, radionuclide bone scans, computed tomography scans, magnetic resonance imaging, and PET-CT scans. * The patient must have an intact anterior wall of spinal canal * The patient must have significant pain (score 6 or above,)which appears to be related to the radiographically documented metastatic vertebra(e) in concern, as measured by the "Visual Analog Scale" * The patient must be surgically and medically accepted for vertebroplasty/kyphoplasty operation * Karnofsky Performance status \>40 * Expected life expectancy of 6 months or greater, as estimated by the physician in charge. * The patient must sign a study specific informed consent prior to enrollment Exclusion Criteria: * Epidural soft tissue component * Patients with vertebral metastases and with clinical or radiographic evidence of spinal cord or cauda equina impingement (effacement) or compression * Inability to undergo anesthesia * Hematologic primary malignancies Patients received systemic radiotherapy (89SR or 153SM)within 30 days prior to enrollmen