CompletedNot Applicable

Low Sodium Diet and Behavioral Intervention for Reversing Arterial Stiffening in Overweight Individuals

United States349 participantsStarted 2007-01

Plain-language summary

Obese individuals are at risk for developing cardiovascular disease (CVD). Increasing physical activity, losing weight, and reducing sodium intake may reverse arterial stiffness and blood vessel damage that is linked to obesity. This study will evaluate the effectiveness of a low sodium diet and a behavioral weight loss intervention in reducing arterial stiffness in overweight young adults.

Who can participate

Age range20 Years – 45 Years

SexALL

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Inclusion Criteria: * Body mass index (BMI) between 25 and 35 Exclusion Criteria: * High blood pressure currently being treated with medication * Blood pressure greater than or equal to 140/90 mm Hg on two consecutive study visits * Diabetes, defined as either a fasting glucose test result of .126 or current use of hypoglycemic medications * Currently taking hyperlipidemia medication * Currently taking vasoactive medications * History of known atherosclerotic disease (e.g., angina, heart attack, lower extremity arterial disease) * Underlying inflammatory condition (e.g., systemic lupus erythematosus, rheumatoid arthritis) * Chronic infection * Current participation in a formal exercise or weight loss program * Pregnant or planning to become pregnant during the study

What they're measuring

Arterial stiffness

Timeframe: Measured at Month 6

Trial details

NCT IDNCT00366990

SponsorUniversity of Pittsburgh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2009-12

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