A Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment (PVD) (NCT00347646) | Clinical Trial Compass
TerminatedPhase 1/2
A Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)
Stopped: Lack of Efficacy
United States4 participantsStarted 2006-09
Plain-language summary
Plasmin is expected to create a posterior vitreous detachment (PVD) when injected directly into the eye. The pharmacological creation of a PVD may be beneficial in helping to treat a variety of conditions.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients who are in need of a vitrectomy.
Exclusion Criteria:
* A PVD in the study eye as assessed by the investigator using ophthalmic and alternative examination techniques.
* A history of vitrectomy in the study eye.
* A media opacity that precludes quality examination of the vitreous and fundus in the study eye.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before it finished — can you tell me why it was stopped, and what that means for how much we know about whether plasmin is safe or effective for vitreoretinal traction syndrome?
2Since this was a Phase 1/2 study, the main goal was still testing safety and early effectiveness — are there other completed or ongoing trials on plasmin or similar enzyme treatments that might give us more reliable data to go on?
3The trial was measuring whether plasmin could create a posterior vitreous detachment — is that the right treatment goal for my specific situation, and are there other ways to achieve that without an experimental drug?
4Given that this study was terminated, is standard surgery like vitrectomy still the most proven option for my type of vitreoretinal traction, and how would the risks of surgery compare to what was being tested here?
5Are there any other clinical trials currently enrolling patients with vitreoretinal traction syndrome that might be worth looking into, now that this one is no longer active?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.