CompletedPhase 3

Autologous ex Vivo Conjunctival Epithelial Cell Expansion for Ocular Surface Transplantation

Singapore80 participantsStarted 2001-10

Plain-language summary

To evaluate the use of cultivated conjunctival epithelial equivalents for the treatment of ocular diseases

Who can participate

Age range

21 Years – 90 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients with ocular surface disorders, e.g. primary pterygium, scheduled for elective surgical excision
. Indications for surgery will be the presence of ocular surface symptoms in the affected eye, loss of visual acuity from visual axis obscuration or irregular astigmatism, or cosmesis.
. Only one eye of a patient will be eligible for study entry.
. Patients who are adult males and females who are aged 21 or older, and are considered mentally sound
. Patients who are willing to undergo long-term follow-up, as outlined in this protocol
. Patients who have signed an informed consent form that has been approved by the SNEC Ethics Committee.

Exclusion criteria

. Patients less than 21 years of age
. Patients who are incapable, either by law or of mental state, of giving consent in their own right
. Patients who are either unable or unwilling to keep scheduled appointments and adhere to the other aspects of the protocol
. Patients who are pregnant or breastfeeding

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Epithelialisation

Graft integrity

Resolution of inflammation

Visual acuity

Complications

Trial details

NCT IDNCT00346450

SponsorSingapore National Eye Centre

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

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