Radiation in Stage I or Stage II Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery (NCT00346320) | Clinical Trial Compass
CompletedNot Applicable
Radiation in Stage I or Stage II Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery
Canada80 participantsStarted 2006-08-02
Plain-language summary
RATIONALE: Radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
PURPOSE: This phase II trial is studying how well radiation therapy works in treating patients with stage I or stage II non-small cell lung cancer that cannot be removed by surgery.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed non-small cell lung cancer (NSCLC)
* Stage I or II peripheral disease
* T1, N0, M0
* T2 (≤ 5 cm), N0, M0
* T3 (≤ 5 cm, chest wall primary tumor only), N0, M0
* No T2-T3 primary tumors \> 5 cm or any T1-T3 tumor of the mainstem bronchus involvement
* No T1-T3 tumor in the lung apex (i.e., tumor in a position that will result in irradiation of the brachial plexus to the prescribed dose)
* Hilar or mediastinal lymph nodes ≤ 1 cm considered N0
* Any of the following primary cancer types:
* Squamous cell carcinoma
* Adenocarcinoma
* Large cell carcinoma
* Bronchioloalveolar cell carcinoma
* Non-small cell carcinoma not otherwise specified
* Underlying physiological medical condition that prohibits surgery due to a low probability of tolerating general anesthesia, the operation, the postoperative recovery period, or the removal of adjacent functional lung (i.e., medically inoperable)
* Cytologic specimens obtained by brushing, washing, or needle aspiration of defined lesion allowed
* If sputum cytology alone is used for diagnosis, it must be confirmed on a second specimen
* Must develop a radiotherapy plan that meets the dose-volume constraints for critical organs
* No ataxia telangiectasia
PATIENT CHARACTERISTICS:
* ECOG performance status 0-2
* Not pregnant or nursing
* Able and willing to complete a quality of life questionnaire unless not literate in eit…