Family Investigation of Nephropathy and Diabetes (F.I.N.D.) (NCT00342927) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Family Investigation of Nephropathy and Diabetes (F.I.N.D.)
United States9,084 participantsStarted 2001-03-07
Plain-language summary
The Family Investigation of Nephropathy and Diabetes (FIND) is a multicenter study designed to identify genetic determinants of diabetic kidney disease. FIND will be conducted in eleven centers and in many ethnic groups throughout the United States. Two different strategies will be used to localize genes predisposing to kidney disease: a family-based genetic linkage study and a case-control study that utilizes admixture linkage disequilibrium. The center based at the Phoenix office of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK-Phoenix) will conduct family-based linkage studies among American Indian populations in the southwestern United States.
Participants (index cases) with diabetes and kidney disease will initially be recruited, and their parents and siblings will also be invited to participate. Genetic material from these participants will be used to genotype markers throughout the genome. Linkage analysis will be conducted to identify particular chromosomal regions containing genes that influence susceptibility to diabetic kidney disease. Linkage analyses will also be used to identify genes influencing traits related to diabetic kidney disease, such as serum creatinine, urinary protein excretion, plasma glucose levels, blood pressure and blood lipid levels. Regions that show evidence for linkage will then be examined in more detail, with both genetic linkage and association studies, to attempt to identify the specific genes that influence diabetic kidney disease, or related traits.
The identification of genes that influence susceptibility to diabetic kidney disease will lead to a better understanding of how kidney disease develops. In the long run, this may lead to improved treatment and prevention of diabetic kidney disease....
Who can participate
Age range
18 Years – 99 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Biopsy proven diabetic nephropathy (by medical record review):
. Nodular and/or diffuse increases in the mesangial matrix accumulation; and
. Thickened glomerular basement membranes and/or arteriolar hyalinization; and
. Absence of mesangial immunoglobulin or paraprotein deposits by immunoflorecscence microscopy, absence of amyloid deposits by Congo Red staining or electron microscopy, absence of electron dense deposits within the glomerular basement membrane or glomerular capillary subendothelial space; and
. Overt proteinuria, defined as ACR greater than or equal to 300 mg/g, urinary protein creatinine ratio greater than or equal to 0.5 g/g, urinary albumin excretion greater than or equal to 300 mg/24 hr, or urinary protein excretion greater than or equal to 0.5 g/24 hr.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is focused on family-based investigation of diabetic nephropathy and kidney disease, does it mean my relatives might also need to be involved, and how would that work logistically for our family?
2This trial is listed as 'active but no longer recruiting' — does that mean there's no way for me to participate, or are there related studies on diabetic kidney disease that my doctor could connect me with instead?
3Since this appears to be an observational or genetic study rather than a treatment trial, would joining something like this actually change how my diabetes or kidney disease is managed, or would I still need to pursue separate treatment options?
4Given that the study is looking at the hereditary patterns of diabetic nephropathy, should I be asking my doctor to evaluate my kidney function more closely now, especially if I have family members who already have diabetic kidney disease?
5Are there current standard-of-care treatments for diabetic kidney disease that my doctor thinks I should consider while this research study is ongoing, rather than waiting to see what this type of investigation uncovers?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Diabetes and diabetic kidney disease.
Timeframe: throughout the study
Trial details
NCT IDNCT00342927
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)