Treatment of Hypochondriasis With CBT and/or SSRI

Inclusion Criteria * Meets DSM-IV criteria for hypochondriasis; ascertained by Structured Diagnosis for Hypochondriasis module of SCID-I, and meets a hypochondriasis severity rating of at least "moderate". * Drug free for 6 weeks of all psychoactive or investigational medications (seven weeks for fluoxetine). * Approval from treating physician if concomitant psychoactive medications need to be withdrawn prior to study participation. * English fluency and literacy. Exclusion Criteria * Pregnant or nursing mothers and women of childbearing potential who are not taking adequate birth control precautions. * Any of the following Axis I mental disorders: chronic pain syndrome, schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder, alcohol abuse or dependence disorder (current or within the last six months), or substance abuse or dependence disorder (current or within the last twelve months). Patients with other comorbid psychiatric disorders are eligible based on the following three criteria: hypochondriasis must be the predominant presenting disorder; patient can not have a major co-morbid psychiatric disorder rated as "severe" on the Clinical Global Impressions Scale (CGI Scale); and patients can not have a co-morbid psychiatric disorder that causes significant functional impairment (significant functional impairment will be defined as an impairment that interferes in a marked way with expected role functioning, vocational and/or interpersonal). * Suic…