Active — Not RecruitingPhase 2

Combination Chemotherapy, Radiation Therapy, and Bevacizumab in Treating Patients With Newly Diagnosed Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

United States29 participantsStarted 2006-06-15

Plain-language summary

This clinical trial studies combination chemotherapy, radiation therapy, and bevacizumab in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as cisplatin, etoposide, and docetaxel, work in different ways to stop the growth of \[cancer/tumor\] cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving more than one drug (combination chemotherapy) together with radiation therapy and bevacizumab may kill more tumor cells.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Histologically or cytologically confirmed single, primary, bronchogenic, non-small cell lung cancer (NSCLC) * Newly diagnosed disease * Unresectable disease * No more than 1 parenchymal lesions on same or opposite sides of the lungs * Meets 1 of the following stage criteria: * Stage IIIA (N2) disease meeting the following criteria: * N2 mediastinal lymph nodes must be multiple and/or bulky on CT scan or x-ray so that the patient is not a candidate for induction chemotherapy or chemoradiotherapy followed by surgical resection * N2 status must be documented by ≥ 1 of the following methods: * Histologically or cytologically confirmed N2 disease by exploratory thoracotomy, thoracoscopy, mediastinoscopy, mediastinotomy, Chamberlain procedure, Wang needle biopsy (WNB), fine needle aspiration (FNA) under bronchoscopic or CT guidance, or any other method * Node positive by fludeoxyglucose-positron emission tomography (FDG-PET) scan * Nodes \> 3 cm on CT scan * Paralyzed left true vocal cord with separate left lung primary distinct from anterior-posterior window nodes on CT scan * Stage IIIB disease meeting ≥ 1 of the following criteria: * Histologically or radiographically confirmed positive N3 nodes\*, documented by ≥ 1 of the following methods: * FNA, core needle biopsy (CNB), or excisional biopsy of supraclavicular N3 nodes * Biopsy of contralateral mediastinal N3 nodes by mediastinoscopy, media…

What they're measuring

Adverse Events

Timeframe: Up to one year

Trial details

NCT IDNCT00334815

SponsorNational Cancer Institute (NCI)

Sponsor typeNIH

Study typeINTERVENTIONAL

Primary completion2014-07-01

Results submitted2015-09-22