Promoting Tolerance to Peanut in High-Risk Children

Inclusion Criteria: * Able to consume solid food * Allergy to eggs and/or severe eczema * Informed consent obtained from parent or guardian. Exclusion Criteria: * Clinically significant chronic illness. Participants with eczema or recurrent wheeze are not excluded. * Positive skin prick test for peanut allergen with a wheel diameter greater than 4 mm in the presence of a negative saline control * Previous or current consumption of peanut protein that exceeds 0.2 g of peanut protein on at least one occasion or 0.5 g over a single week * Investigator-suspected allergy to peanut protein * Investigator-suspected allergy to peanut protein in care provider or current household member. * Diagnosis of persistent asthma * ALT (SGPT) or bilirubin greater than 2 times the upper limit of age-related normal value * BUN or creatinine greater than 1.25 times the upper limit of age-related normal value * Platelet count less than 100,000/mL, hemoglobin less than 9 g/dL, or investigator-suspected immunocompromise * Unwillingness or inability to comply with study requirements and procedures