CompletedPhase 2/3

Melatonin and Cardiac Outcome After Major Surgery

Denmark52 participantsStarted 2007-01

Plain-language summary

The purpose of this study is to assess whether treatment with melatonin can reduce cell damage and inflammatory stress response and thereby occurrence of myocardial injury after abdominal aortic surgery.

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Indication for elective abdominal aortic aneurism surgery or periphery atheroscleroses with indicated protheses operation * Patients between 18 and 80 years old Exclusion Criteria: * Patients with ASA class \> 3 * Anticoagulation therapy (marevan and marcoumar) * Preoperative therapy with opioid, anxiolytic and hypnotic medication * Renal insufficient (preoperative creatinin \> 200 mmol/l) * Well-known liver insufficient * Alcohol consumption (more than 5 drinks) * Compliance (language difficulty, mental problems etc.) * Pregnancy and breast-feeding * Lack of written consent

What they're measuring

Cardiac morbidity

Timeframe: 30 days

Trial details

NCT IDNCT00315926

SponsorUniversity Hospital, Gentofte, Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-07

View on ClinicalTrials.gov More Aortic Aneurysm trials