CompletedNot Applicable

Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee

Canada80 participantsStarted 2005-12

Plain-language summary

This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone. Furthermore, the effect of BST-CarGel in decreasing cartilage related pain and improving cartilage-related function in the knee will be assessed.

Who can participate

Age range18 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Between 18 and 55 years of age * Focal articular cartilage lesion on the medial femoral condyle * Grade 3 or 4 acute (traumatic) or chronic (degenerative) lesion * Stable knee Exclusion Criteria: * Multiple lesions or kissing lesions * Clinically relevant compartment malalignment (\> 5 degrees) * Undergone ligament treatments in the affected knee within 2 years prior to trial * Inflammatory arthropathy, such as rheumatoid arthritis, systemic lupus, or active gout * Previous surgical cartilage treatments in the affected knee in the last 12 months

What they're measuring

Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI.

Timeframe: 12 months

Repair Cartilage T2 Relaxation Time

Timeframe: 12 months

Trial details

NCT IDNCT00314236

SponsorPiramal Healthcare Canada Ltd

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2011-02

Results submitted2015-11-05

View on ClinicalTrials.gov More Knee Injuries trials