ACT34-CMI -- Adult Autologous CD34+ Cells

Inclusion Criteria: * Canadian Cardiovascular Society (CCS) functional class III or IV chronic refractory angina * subjects without control of their angina symptoms, in spite of maximal tolerated doses of anti-anginal drugs, must be on optimal therapy for their angina and on a stable anti-anginal medication regimen for at least 1 month prior to entering the screening period of the study * identified as unsuitable for conventional revascularization * recent coronary angiogram (within the last 12 months) to document the coronary anatomy and to verify the revascularization procedures * subjects must have objective evidence of inducible ischemia or viable myocardium in the potential target injection zone * a left ventricular ejection fraction equal to or greater than 25% by ECHO or single photon emission computed tomography (SPECT) at screening * subjects must experience at minimum an average of 7 angina or anginal equivalent episodes per week * subjects must be able to complete a minimum of 3 minutes but nor more than 10 minutes on a treadmill following the Modified Bruce Protocol * subjects must experience angina or anginal equivalent episodes during the screening exercise treadmill test * female subjects must either be no longer capable of reproduction or using medically valid contraception to prevent pregnancy during the study * subjects must be willing and able to comply with specified follow-up evaluations Exclusion Criteria: * predominant congestive heart failure * myoc…