CompletedNot Applicable

MIDCAB Versus DES in Proximal LAD Lesions

Germany130 participantsStarted 2003-01

Plain-language summary

Percutaneous coronary intervention with a sirolimus-coated stent compared to minimally invasive bypass surgery in patients with isolated proximal left anterior descending coronary arteries in terms of non-inferiority of an end point combining mortality, acute myocardial infarction and rate of reintervention of the target vessel within one year.

Who can participate

Age range18 Years – 100 Years

SexALL

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Inclusion criteria

✓. Single-vessel disease of the proximal LAD with a stenosis \> 50% (multivessel disease only if further coronary vessel stenoses do not require treatment)
✓. Patients with angina pectoris (CCS 1-4)
✓. Asymptomatic patients if clear signs of ischemia in the segments supplied by the LAD as assessed by bicycle ergometry or treadmill and/or scintigraphically and/or stress echo
✓. Patients for whom both methods of treatment are equally possible

Exclusion criteria

✕. Informed consent of the patient.
✕. Patients \< 18 years
✕. Pregnancy
✕. Previous coronary artery bypass surgery
✕. Concomitant diseases that lead to a greater risk for each of the treatment strategies
✕. Significant peripheral arterial occlusive disease
✕. Concomitant disease with limited life expectancy (e.g. malignant tumours that have not been curatively treated)
✕. Objective follow-up examination not possible due to physical or mental handicap

What they're measuring

Major adverse cardiac events

Timeframe: 12 months

Trial details

NCT IDNCT00299429

SponsorUniversity of Leipzig

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-07

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