CompletedPhase 4

Early Childhood Malaria Prevention With Maloprim in The Gambia

The Gambia2,253 participantsStarted 1982-04

Plain-language summary

A trial was conducted in the 1980s to compare two strategies for control of malaria in young children aged 3-59 months: treatment with chloroquine versus treatment combined with fortnightly chemoprophylaxis with Maloprim. The impact on mortality and morbidity was assessed at the time, and their cognitive abilities and educational outcomes were assess 14 years later in 2001. The hypothesis was that the chemoprophylaxis would reduce morbidity and mortality and would improve cognitive abilities and educational outcomes in the long term

Who can participate

Age range3 Months – 59 Months

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * For original trial: Children aged 3-59 months present in participating villages * For follow-up: Children who were in original trial for at least 1 year. Exclusion Criteria: * For original trial: None * For follow-up: Children with mental or physical disabilities who were unable to do cognitive tests

What they're measuring

Mortality

Episodes of Fever Associated with Malaria Parasitaemia

Cognitive Abilities in late adolescence

Educational Attainment (Years spent at school)

Trial details

NCT IDNCT00294580

SponsorImperial College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

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