Efficacy and Safety of Two Doses of Liarozole vs. Placebo for the Treatment of Lamellar Ichthyosis

Inclusion Criteria: * Subjects of either sex aged 14 years or older. * Clinical diagnosis of lamellar ichthyosis * Women of childbearing potential should use appropriate contraception * Women of childbearing potential should have a negative pregnancy test at screening visit. * Subjects are, except for their lamellar ichthyosis, in good general health. * Subjects and legal representative(s), if applicable, signed informed consent. Exclusion Criteria: * Subject is receiving topical (except emollient), UV treatment or systemic treatment for ichthyosis. * Subject is pregnant or breast feeding. * History or suspicion of alcohol or drug abuse. * Significant co-existing diseases. * Clinically significant abnormal ECG * History of hypersensitivity to retinoids or any of the ingredients in the trial medication. * Clinically relevant laboratory abnormalities at screening. * Use of immune-suppressive drugs including topical or systemic corticosteroids. * Participation in an investigational trial 30 days prior to the start of the trial.