Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia

Inclusion Criteria: * Treatment-seeking male or female outpatients, 12-45 years old * Meet the definition of one or more prodromal syndromes according to the Criteria of Prodromal Syndromes (COPS) derived using the SIPS/SOPS scales. * Possession of a level of understanding sufficient to communicate with the investigator and to understand the nature of the study * Agreement to participate in the study and sign informed consent. Minors will be required to give written informed consent with written consent from a parent or guardian Exclusion Criteria: * Meeting criteria for past or current DSM-IV psychotic disorder * Judged clinically to suffer from a psychiatric disorder (e.g. ADHD, mania, depression) that could account for the inclusion symptoms * Judged clinically to be at suicidal or homicidal risk * Symptoms judged clinically to be sequelae of drug or alcohol abuse * IQ of less than 80 * Seizure disorder without a clear or resolved etiology * Female patients who are pregnant or lactating; female patients who are not pregnant or lactating, if sexually active, must be using medically accepted means of contraception * Taking non-protocol psychiatric medications within two weeks of randomization or depot psychiatric medications three months prior to study entry * Individuals suffering from an unstable and/or untreated medical disorder will not be entered in the study