CompletedPhase 4

Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

United States70 participantsStarted 2006-10

Plain-language summary

The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients at risk of a first heart attack.

Age range40 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. waist measuring more than 40 inches (for men) or more than 35 inches (for women),
✓. high density lipoprotein (HDL) cholesterol levels lower than 40 milligrams per deciliter (mg/dl) in men or 50 mg/dl in women,
✓. triglyceride (TG) levels above 150 mg/dl,
✓. blood pressure greater than 130 millimeters of mercury (mmHg) systolic or 85 mmHg diastolic,
✓. fasting blood sugar greater than 110 mg/dl

✕. Patients taking greater than 81mg aspirin daily.
✕. Patients taking anti-platelet drugs such as clopidogrel or non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulant drugs such as warfarin, during the last two weeks.
✕. Patients taking any of the following medications for less than 3 months, or who plan to take them for the first time during the next 3 months: ACE-inhibitors, angiotensin receptor blockers, calcium channel blockers, or statins.
✕. Patients who are currently cigarette smokers.
✕. Women patients who are pregnant, planning to become pregnant, nursing a child, or taking hormone replacement therapy.
✕. Patients with any coagulation, bleeding or blood disorders.
✕. Patients who are sensitive or allergic to aspirin.
✕. Patients with documented history of any gastrointestinal disorders, including bleeding ulcers.

Change in Nitric Oxide Formation From Baseline to 3 Months

Timeframe: Baseline to 3 Months (90-97 days)

NCT IDNCT00272311

SponsorFlorida Atlantic University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2009-01

Results submitted2012-05-16

Who can participate

Age range40 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. waist measuring more than 40 inches (for men) or more than 35 inches (for women),
✓. high density lipoprotein (HDL) cholesterol levels lower than 40 milligrams per deciliter (mg/dl) in men or 50 mg/dl in women,
✓. triglyceride (TG) levels above 150 mg/dl,
✓. blood pressure greater than 130 millimeters of mercury (mmHg) systolic or 85 mmHg diastolic,
✓. fasting blood sugar greater than 110 mg/dl

✕. Patients taking greater than 81mg aspirin daily.
✕. Patients taking anti-platelet drugs such as clopidogrel or non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulant drugs such as warfarin, during the last two weeks.
✕. Patients taking any of the following medications for less than 3 months, or who plan to take them for the first time during the next 3 months: ACE-inhibitors, angiotensin receptor blockers, calcium channel blockers, or statins.
✕. Patients who are currently cigarette smokers.
✕. Women patients who are pregnant, planning to become pregnant, nursing a child, or taking hormone replacement therapy.
✕. Patients with any coagulation, bleeding or blood disorders.
✕. Patients who are sensitive or allergic to aspirin.
✕. Patients with documented history of any gastrointestinal disorders, including bleeding ulcers.