A Study to Determine the Safety and Effectiveness of Epoetin Alfa in Facilitating Self-donation of Blood Before Surgery in Patients Who Are Not Anemic and Who Will be Undergoing Orthopedic or Heart and Blood Vessel Surgery

Inclusion Criteria: * Patients scheduled for orthopedic or heart and blood vessel surgery * requirement of 3 or more units of blood * who are non-anemic (hemoglobin within normal range of 12.0 - 18.0 grams/deciliter) * having laboratory tests within normal ranges Exclusion Criteria: * Patients with history of any primary blood disease * having signs and symptoms of significant disease/dysfunction, such as signs and symptoms of significant heart and blood vessel disease (in patients undergoing orthopedic surgery) or severe alteration in rhythm of the heartbeat, persistent brief attacks of chest pain, or significant heart failure in which the heart is unable to maintain adequate circulation of blood (in patients undergoing heart and blood vessel surgery) * having uncontrolled high blood pressure or signs and symptoms of significant dizziness, faintness, or lightheadedness which appear only on standing and are caused by low blood pressure * who have received a blood transfusion within 1 month before the start of the study * having a body weight greater than 100 kilograms (approximately 220 pounds)