Effect of Growth Hormone in Children With Growth Hormone Deficiency

Inclusion Criteria: * Clinically suspected GHD * Height \< -2.0 SDS * Serum IGF-I less than or equal to -1.0 SDS * Bone age less than or equal to 9 years for boys and less than or equal to 7 years for girls. * Puberty Tanner Stage I Exclusion Criteria: * Previous use of growth hormone * Growth retardation attributable to causes other than GHD (e.g. inborn errors of metabolism, primary bone disease, chromosomal disorders, etc.) * Intrauterine growth retardation: birth weight \< 3rd percentile. * Administration of other growth-altering medications. * Evidence of any malignancy or intracranial tumors.