Ex Vivo Expansion of Mafosfamide Purged CD34+ Cells in Patients With Acute Leukemia

DISEASE CHARACTERISTICS: * Diagnosis of acute leukemia meeting 1 of the following criteria: * High-risk acute myeloid leukemia (AML) in first complete remission (CR) with no matched family donor available, including any of the following types: * Secondary AML * AML with chromosome 5 or 7 abnormalities * AML with trisomy 8 * AML with 6;9 chromosomal translocation * AML with 11q23 chromosomal abnormality * AML with multiple or complex chromosomal abnormalities * AML with FAB M6 or M7 * AML in second CR (CR2) with no eligible HLA-identical sibling donor available * High-risk acute lymphoblastic leukemia (ALL) with no eligible HLA-identical sibling donor available, including any of the following types: * Philadelphia chromosome-positive ALL * ALL with 11q23 chromosomal abnormality * ALL in CR2 * Eligible for and willing to undergo bone marrow transplantation * No intermediate- or good-risk acute leukemia in CR1 Exclusion Criteria * Availability of a suitable matched HLA-identical sibling marrow donor * Intermediate or good risk acute leukemia in CR1 (39) * Age greater than 70 * Weight less than 10 kg * Any risk of pregnancy - all female patients must have an effective form of contraception or be infertile due to hysterectomy, fallopian tube, surgery or premature menopause. * HIV Infection: Patients must be HIV negative for inclusion. * Poor organ function as defined in the BMT Policies and Procedures Manual.