CompletedNot Applicable

Characteristics of Nondystrophic Myotonias

United States, Canada94 participantsStarted 2006-02

Plain-language summary

Nondystrophic myotonias (NDM) are muscle disorders caused by genetic abnormalities in certain muscle cell membrane proteins. Individuals with NDM experience limited muscle relaxation, which causes pain, weakness, and impaired physical activity. The purpose of this study is to better characterize the clinical features and symptoms of NDM.

Who can participate

Age range6 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical symptoms or signs suggestive of myotonia * Presence of myotonic potentials on electromyography (EMG) * Persistence of symptoms and signs after discontinuation of medications that produce myotonia; such medications include fibric acid derivatives, hydroxymethylglutaryl CoA reductase inhibitors, chloroquine, and colchicine * Absence of features suggestive of myotonic dystrophy, including ptosis, temporal wasting, mandibular weakness, cataracts occurring before age 50, and evidence of multisystem defects (cardiac conduction defects, hypogonadism) Exclusion Criteria: * Any other neurologic condition that might affect the assessment of the study measurements

What they're measuring

Examine the frequency applicable events related to Nondystrophic Myotonia

Timeframe: Baseline - 3 yrs

Trial details

NCT IDNCT00244413

SponsorRichard Barohn, MD

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2012-09

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