A Study of the Function of Hormones Present In Taste Buds (NCT00233298) | Clinical Trial Compass
CompletedNot Applicable
A Study of the Function of Hormones Present In Taste Buds
United States225 participantsStarted 2005-05-26
Plain-language summary
The purpose of this study is to find out whether the hormones in the taste buds are affected by tasting and eating food, and also whether these hormone levels are affected by an increase in body weight or type 2 diabetes.
Who can participate
Age range12 Years – 50 Years
SexALL
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Inclusion criteria
✓. Males or females age 20 to 50
✓. body weight \> 50 kg (110 pounds)
✓. Group A
✓. BMI \< 25 kg/m(2)
✓. healthy
✓. Group B
✓. BMI greater than or equal to 30 kg/ m(2)
✓. healthy
Exclusion criteria
✕. Pregnancy (pregnancy has been shown to be associated with decrease in insulin sensitivity
✕. Group A and B subjects cannot have FPG greater than or equal to 100 mg/dl or 2-hr OGTT greater than or equal to 140 mg/dl
✕. Group D subjects cannot have FPG \> 240 mg/dl during the screening visit
✕. Group D subjects cannot have their morning fasting finger-stick glucose \> 240 mg/dl during the 5 days (3 days for glucophage) prior to the visit when their oral hypoglycemic agent(s) are discontinued
✕. Subjects with type 2 diabetes on insulin therapy
✕. Hematocrit \< 36% for women and \< 38% for men
✕. Peanut allergy
What they're measuring
1
Whether CLP-1 and PYY are involved in the cephalic phase response during feeding
Timeframe: 12 months
2
Differences in response among healthy, healthy obese, pre-diabetic or 3 diabetes