CompletedNot Applicable

A Study of the Function of Hormones Present In Taste Buds

United States225 participantsStarted 2005-05-26

Plain-language summary

The purpose of this study is to find out whether the hormones in the taste buds are affected by tasting and eating food, and also whether these hormone levels are affected by an increase in body weight or type 2 diabetes.

Who can participate

Age range

12 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Males or females age 20 to 50
. body weight \> 50 kg (110 pounds)
. Group A
. BMI \< 25 kg/m(2)
. healthy
. Group B
. BMI greater than or equal to 30 kg/ m(2)
. healthy

Exclusion criteria

. Pregnancy (pregnancy has been shown to be associated with decrease in insulin sensitivity
. Group A and B subjects cannot have FPG greater than or equal to 100 mg/dl or 2-hr OGTT greater than or equal to 140 mg/dl
. Group D subjects cannot have FPG \> 240 mg/dl during the screening visit
. Group D subjects cannot have their morning fasting finger-stick glucose \> 240 mg/dl during the 5 days (3 days for glucophage) prior to the visit when their oral hypoglycemic agent(s) are discontinued

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Whether CLP-1 and PYY are involved in the cephalic phase response during feeding

Timeframe: 12 months

Differences in response among healthy, healthy obese, pre-diabetic or 3 diabetes

Timeframe: 12 months

Trial details

NCT IDNCT00233298

SponsorNational Institute on Aging (NIA)

Sponsor typeNIH

Study typeOBSERVATIONAL

View on ClinicalTrials.gov More Diabetes trials