Propofol Injection for Daily Headache

Inclusion criteria * Adult subjects (18-65 years) with CDH by the criteria of Silberstein and Lipton.41 i.e. on the basis of pre-randomization history suffer chronic headaches lasting more than 4 hours a day for more than 15 days a month. * Previously investigated to exclude serious treatable pathology. * On the basis of the pre-randomization headache diary: the average pain intensity during each episode should be at least 5 /10 on the Numerical Rating Scale (NRS) on 4 days out of 7. * Quality of life and function should be impaired as evidenced by a (pre-randomization) Headache Disability Index (HDI) of at least 40. Exclusion criteria History of the following: * Known or suspected allergy to propofol, intralipid or midazolam, * In emergency or life-threatening situations, * Those having language barriers (e.g. illiterate, not English-speaking, dysphasic), * Known or suspected difficult airway or sleep apnea, * Severe respiratory disease, * Neuromuscular disease, * Seizure disorder, * Severe cardiac disease, * Severe gastroesophageal reflux disease, * Pancreatitis, * Lipid disorders, * Receiving Total Parenteral Nutrition, * Body mass index \> 35, diabetes or major endocrine disorder, * Hepatic or renal failure, * Unstable psychiatric disorder, * Known drug abuse, * Pregnancy, * Cognitively impaired.