Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF). (NCT00221013) | Clinical Trial Compass
CompletedPhase 4
Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF).
Australia1,508 participantsStarted 2005-11
Plain-language summary
This study seeks to determine if increasing the dose of continuous renal replacement therapy (CRRT) reduces 90-day all cause mortality in Intensive Care Unit (ICU) patients with severe acute renal failure (ARF).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. The treating clinician believes that the patient requires CRRT for acute renal failure.
. The clinician is uncertain about the balance of benefits and risks likely to be conferred by treatment with higher intensity or lower intensity CRRT.
. The treating clinicians anticipate treating the patient with CRRT for at least 72 hours.
. Informed consent has been obtained
. The patient fulfils ONE of the following clinical criteria for initiating CRRT:
Exclusion criteria
. Patient age is \<18 years.
. Death is imminent (\<24 hours).
. There is a strong likelihood that the study treatment would not be continued in accordance with the study protocol.
. The patient has been treated with CRRT or other dialysis previously during the same hospital admission.
. The patient was on maintenance dialysis prior to the current hospitalisation.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Death from all causes at 90 days after randomisation.
. The patient's body weight is \<60 kg or \>100kg.
. Any other major illness that, in the investigator's judgment, will substantially increase the risk associated with the subject's participation in this study.