Galantamine in the Treatment of Post-Traumatic Headache (NCT00219869) | Clinical Trial Compass
UnknownPhase 4
Galantamine in the Treatment of Post-Traumatic Headache
United States30 participantsStarted 2005-07
Plain-language summary
Most patients with CPTH present with additional major cognitive, behavioral and somatic problems. Most drugs used currently have a negative influence on cognition. Therefore, treatment strategies addressing both the headache and cognitive disturbances in patients with CPTH are necessary. (CPTH; Chronic Post Traumatic Headache).
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Age range 18-75 CPTH according to ICHD-2 Fertile woman using adequate birth control Willing and able to give informed consent Willing and able to complete the entire course of the study to comply with study instructions Stable does of preventive medication
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Exclusion Criteria:
Subject is pregnant or lactating Significant medical or psychiatric disease Previous failure to 4 or more adequate trials of preventive medication Patient on non-stable dose of medication used to prevent CPTH
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Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial uses galantamine, a drug typically used for Alzheimer's disease, can you explain why it might help with post-traumatic headaches and whether its known side effects are a concern for my specific situation?
2This trial measures success by counting pain-free days over 3 months — based on my current headache pattern and frequency, is that a realistic and meaningful goal for someone in my situation?
3The trial also involves cognitive retention disorders alongside headache — do my symptoms match what this study is looking at, and would that affect whether this might be worth discussing as an option?
4The recruitment status for this trial is listed as unknown, which may mean it's no longer actively enrolling — can you find out if this study is still running, and if not, whether its results are available to inform my treatment?
5Since this is a Phase 4 trial, meaning the drug is already approved for other uses, what does that tell us about how much safety information exists for galantamine, and how does that compare to other treatments you might recommend for post-traumatic headache?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Primary Headache Efficacy Measure; number of pain free days after 3 months