Progesterone for the Treatment of Cocaine Dependence - 1

Inclusion Criteria: * Smoked at least 1 gram of cocaine each week for the 6 months prior to study entry * Agrees to use an adequate method of contraception for the duration of the study * If female, current regular menses Exclusion Criteria: * Major psychiatric illnesses, including psychotic mood and anxiety disorders * Current dependence on alcohol or drugs other that cocaine or nicotine * History of major medical illnesses, including liver disease, abnormal vaginal bleeding, suspected or known breast cancer, thrombophlebitis, or other medical conditions * Current use of oral contraceptives or other types of hormonal contraceptives * Amenorrhea * Currently on parole or probation * Received treatment for chemical dependency within the 6 months prior to study entry * Known allergy to progesterone or peanuts