CompletedPhase 4

L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function

France30 participantsStarted 2004-02

Plain-language summary

* exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction * cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal model by L-arginine supplementation * to determine the potential beneficial effect of L-arginine supplementation on exercise capacity and renal function of heart transplant recipients

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male (\> 18 years old) stable heart transplant recipient for at least 6 weeks * Stable treatment for at least 3 months * Sedentary people Exclusion Criteria: * Unstable cardiac pathology * Obesity (IMC \> 40) * Participation in another study in the last month * Chronic renal failure (creatinine clearance \< 20 ml/min) * Renal transplantation * Diabetes * Impossibility to practice exercise test * Nitrate therapy

What they're measuring

Maximal and sub maximal exercise capacity at the end of the 6 weeks L-arginine supplementation. Renal function at the end of the 6 weeks

Trial details

NCT IDNCT00213915

SponsorUniversity Hospital, Strasbourg, France

Sponsor typeOTHER

Study typeINTERVENTIONAL

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