RecruitingNot Applicable

SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era

United States2,500 participantsStarted 2000-03

Plain-language summary

SCOPE is an observational, prospective study of HIV-1 infected volunteers designed to provide a specimen bank of samples with carefully characterized clinical data. SCOPE specimens will be used to examine multiple questions involving virologic, immunologic, and host factors involved in HIV-1 infection, progression, non-progression, response to treatment, control of HIV-1 virus, and evolution of drug resistance.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Documented HIV viral load less than 2000 copies/ml WITHOUT taking antiretroviral therapy
✓. Undetectable HIV viral load with CD4 T-cells consistently less than 350 for the last 12 months while taking a stable antiretroviral regimen.
✓. Antiretroviral naive and planning to start an antiretroviral regimen - any CD4 or HIV viral load acceptable.
✓. Long-term Non Progressors: HIV-positive at least 10 years, no antiretroviral therapy for the past 10 years or more, any viral load acceptable, CD4-T cell count always above 500.

Exclusion criteria

✕. Active opportunistic infection or systemic treatment for opportunistic infection within the last 4 months (oral candidiasis acceptable)
✕. Active treatment for cancer
✕. Active treatment for hepatitis C requiring interferon based therapy
✕. Immunosuppressive therapy taken within the last 4 months

What they're measuring

The general theme of this core is to investigate the relationship between the virologic response to antiretroviral therapy and clinical outcome.

Timeframe: Ongoing

Trial details

NCT IDNCT00187512

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2032-12

Contact for this trial

Rebecca Hoh, M.S., R.D.

415-476-4082 Rebecca.Hoh@ucsf.edu

View on ClinicalTrials.gov More HIV Infections trials