WithdrawnPhase 1/2

Steroids and Antiphospholipid Syndrome- Related Pregnancy Loss

Stopped: Literature highlighted unnecessary side effects from the relevant combination.

United Kingdom0Started 2005-10

Plain-language summary

Does the addition of steroids during the first trimester to the standard aspirin + heparin treatment reduce the miscarriage rates in women with antiphospholipid antibodies and recurrent first trimester miscarriage in those who had an unsuccessful pregnancy with aspirin + heparin?

Who can participate

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: History of 3 or more consecutive miscarriages and positive antiphospholipid antibodies on at least two occasions more than 6 weeks apart before becoming pregnant and an unsuccessful pregnancy with aspirin + heparin with a karyotype of miscarriage either unavailable or normal (46XX/ 46XY). Exclusion Criteria: Abnormal karyotype of women or partner, previous thromboembolism, SLE, diabetes mellitus, hypertension, sensitivity to aspirin, heparin and prednisolone, multiple pregnancy.

What they're measuring

Successful pregnancy outcome

Trial details

NCT IDNCT00180778

SponsorImperial College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2005-10

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