Proteomics of Brain Trauma-associated Elevated Intracranial Pressure (ICP)
United States260 participantsStarted 2004-08-25
Plain-language summary
The specific aim of this research is to determine if the blood from brain-injured patients contains reproducible protein markers that appear prior to elevations in intracranial pressure (ICP).
Who can participate
Age range
14 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Fracture confirmed radiographically
. No head trauma
. No other known inflammatory process or infection
. No history of neurological or psychiatric disorders or alcohol or drug dependency.
. Non-penetrating head trauma manifesting one or more of the following:
. GCS\> 12
. No abnormalities on CT other than contusion
. No operative Lesions
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study has already been completed — is the proteomics data it collected available, and could the findings about proteins linked to elevated intracranial pressure tell us anything useful about my situation?
2Since this was an observational study measuring intracranial pressure rather than testing a treatment, what does research like this mean for the future treatment options being developed for traumatic brain injury?
3This trial focused on identifying biological markers associated with dangerous spikes in brain pressure — based on what's been learned from studies like this, how are doctors currently monitoring and managing elevated intracranial pressure in patients like me?
4Are there any active or follow-up clinical trials building on this kind of proteomics research that might offer new diagnostic or treatment approaches worth considering for traumatic brain injury?
5Given that this was a completed study with no phase designation, meaning it wasn't testing a specific therapy, what standard-of-care treatments are currently available for managing elevated intracranial pressure after a traumatic brain injury?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Elevated intracranial pressure
Timeframe: within the first 10 days post injury
Trial details
NCT IDNCT00178659
SponsorThe University of Texas Health Science Center, Houston