CompletedNot Applicable

ATP/AMP Challenge in Healthy Non-smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)

United Kingdom31 participantsStarted 2002-10

Plain-language summary

In this randomised, cross-over, controlled study, a total of 84 subjects will be included: 12 healthy non-smoking volunteers; 12 current smokers; 30 patients with mild steroid-naïve asthma; and 30 patients with mild-moderate COPD. Each subject will have 1 screening visit (if necessary) and 2 study visits. At visits 2 and 3 the effects of adenosine 5'-triphosphate (ATP) or adenosine 5'-monophosphate (AMP) challenge, given in a random order, will be tested.

Who can participate

Age range21 Years – 85 Years

SexALL

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Inclusion criteria

✓. Healthy non-smokers (n=12)
✓. At risk (current smokers) (n=12)\*
✓. Mild steroid-naïve asthma (n=30)
✓. Mild-moderate COPD (n=30)

Exclusion criteria

✕. Pregnancy, breast-feeding, or planned pregnancy during the study.
✕. Fertile women not using acceptable contraceptive measures, as judged by the investigator
✕. Upper respiratory infection within the last 4 weeks
✕. Subjects who have received research medication within the previous one month
✕. Subjects unable to give informed consent
✕. Any psychiatric condition rendering the patient unable to understand the nature, scope, and possible consequences of the study.

What they're measuring

PC20 of ATP and AMP

Timeframe: On administration

Lung function

Timeframe: On administration

Borg score

Timeframe: On administration

Impulse oscillometry (IOS)

Timeframe: On administration

Trial details

NCT IDNCT00159315

SponsorImperial College London

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2004-10

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