CompletedPhase 3

Salt Reduction on Blood Pressure and Cardiovascular Organ Damage

United Kingdom210 participantsStarted 2004-04

Plain-language summary

The purpose of this study is to determine the effect of a modest reduction in salt intake on blood pressure in white, black and Asian individuals with hypertension or prehypertension, and also to determine whether a modest reduction in salt intake has beneficial effects on the surrogate markers of target organ damage in cardiovascular disease.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with untreated essential hypertension or prehypertension (sitting systolic blood pressure between 120 and 170 mmHg and/or sitting diastolic blood pressure between 80 and 105 mmHg) * Age 18 - 75 years. Exclusion Criteria: * Individuals younger than 18 or older than 75 years * Individuals with severe hypertension i.e. blood pressure \> 170/105 mmHg * Individuals with any secondary cause of hypertension * Individuals with impaired renal function with plasma creatinine greater than 150 umol/L * Individuals with diabetes mellitus * Individuals with malignancy or liver disease * Individuals with ischaemic heart disease or heart failure * Females who are pregnant or breast feeding or on the oral contraceptive pill.

What they're measuring

Blood pressure and markers of target organ damage at 6 weeks of usual salt intake vs those at 6 weeks of reduced salt intake.

Trial details

NCT IDNCT00152074

SponsorSt George's, University of London

Sponsor typeOTHER

Study typeINTERVENTIONAL

View on ClinicalTrials.gov More Hypertension trials