TerminatedNot Applicable

Genetic Study of Nephrolithiasis in Gouty Diathesis

Stopped: Non significative preliminary data

Italy37 participantsStarted 2005-05

Plain-language summary

Gouty diathesis describes uric acid or calcium oxalate nephrolithiasis and low urinary pH (\<5.5). A hereditary component has been outlined for several forms of nephrolithiasis (such as hypercalciuria, hyperoxaluria, cystinuria, renal tubular acidosis), leading to the hypothesis of a genetic predisposition to nephrolithiasis. At the Unit of Nephrology, Ospedali Riuniti di Bergamo, more than 100 patients affected by gouty diathesis are followed. Fifty percent of them has a familiarity for kidney stones formation. The aim of our study is to identify the genetic factors that predispose to the development of nephrolithiasis in patients with gouty diathesis.

Who can participate

Age range10 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * male and female, ≥ 10 years of age * uric acid or calcium oxalate nephrolithiasis * urinary 24 h pH \< 5.5 in absence of high animal protein intake (urinary sulphate excretion \<25 mM/24 h after one week of low animal protein intake) * familial history of kidney stones (at least two first or second degree family members affected) * written informed consent according to the Declaration of Helsinki guidelines Exclusion Criteria: * renal colic in the 4 weeks preceding evaluations * excessive gastrointestinal alkali loses * inability to fully understand the purposes of the study or to provide a written informed consent

Trial details

NCT IDNCT00149305

SponsorMario Negri Institute for Pharmacological Research

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2010-01

View on ClinicalTrials.gov More Nephrolithiasis trials