Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma

Inclusion Criteria: * Histologically confirmed high-grade osteosarcoma, including second malignancies * Localized or metastatic disease * The primary tumor must be located in the limbs or axial skeleton, including any of the following sites\*: * Long bone of upper limb * Short bone of upper limb * Long bone of lower limb * Short bone of lower limb * Vertebral column * Ribs, sternum, clavicle, or scapula * Pelvic bones, sacrum, or coccyx * Tumor (primary, metastatic, or both) resectable OR is expected to become resectable after neoadjuvant induction chemotherapy * Suitable for neoadjuvant chemotherapy * Performance status - Lansky 50-100% (for patients under 16 years of age) * Performance status - Karnofsky 50-100%\* * Performance status - WHO or ECOG 0-2\* * Platelet count ≥ 100,000/mm³ * Neutrophil count ≥ 1,500/mm³ * WBC ≥ 3,000/mm³ * Bilirubin ≤ 1.5 times upper limit of normal * Creatinine clearance ≥ 70 mL/min * Creatinine based on age as follows: * No greater than 1.0 mg/dL (for patients 5 to 10 years of age) * No greater than 1.2 mg/dL (for patients 11 to 15 years of age) * No greater than 1.5 mg/dL (for patients over 15 years of age) * Ejection fraction ≥ 50% by radionuclide angiogram * Shortening fraction ≥ 28% by echocardiogram * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception * No known HIV positivity * No prior chemotherapy for any disease * Prior radiotherapy for anothe…