Diuretics In the Management of Essential Hypertension (DIME) Study (NCT00131846) | Clinical Trial Compass
CompletedPhase 4
Diuretics In the Management of Essential Hypertension (DIME) Study
Japan1,130 participantsStarted 2004-04
Plain-language summary
The purpose of DIME is to evaluate the safety (i.e. new onset of diabetes and other metabolic adverse events), efficacy and cost-effectiveness of antihypertensive treatment with low dose diuretics. The researchers' hypothesis is that use of low dose thiazide diuretics is metabolically safe when used with other appropriate antihypertensives, effective in reduction of blood pressure and cheaper than treatment without diuretics. Therefore, this study is an equivalence trial.
Who can participate
Age range
30 Years – 79 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 30 to 79 years
* With blood pressure being \>150/\>90 if they are not on any antihypertensive treatment
* With blood pressure being \>140/\>90 if they are already on antihypertensive drugs
* No history of type 2 diabetes
* No history of gout
Exclusion Criteria:
* With supine blood pressure being \>200/\>120
* Patients already on antihypertensive treatment if duration of treatment and drugs used are not identified
* Patients already on thiazide diuretics
* With type 2 diabetes
* With gout or hyperuricaemia (\>8.0 mg/dl)
* With hypokalemia（\<3.5mmol/L）
* With erectile dysfunction
* With renal dysfunction (s-creatinine \> 2.0 mg/dL)
* With history of serious adverse reaction to thiazide diuretics
* With history of stroke or myocardial infarction within 6 months
* With history of percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) within 6 months or in whom these interventions are planned
* With heart failure or left ventricular dysfunction (ejection fraction\<40%)
* Patients who should be on thiazide diuretics
* With history of malignant tumor within 5 years
* Pregnant, possibility of pregnancy, or during breast feeding
* Patients who are deemed not eligible for this study for any reason
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.