Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness

Inclusion Criteria: * Males and non-pregnant/non lactating females \>5 years of age * One onchocercal nodule in an anatomical position where it can be easily removed surgically Exclusion Criteria: * Pregnancy (based on urine pregnancy test) * Breast-feeding * Women taking oral contraceptives * Allergy or other adverse reaction to either medication * Use of other medications that might interact with rifampin * Clinical evidence of liver disease (jaundice, swollen abdomen) * Clinical evidence of chronic disease/alcoholism