RAPAMYCIN FOR KIDNEY ANGIOMYOLIPOMAS

Inclusion Criteria: * Age 3-65 years old (females of reproductive age must not be pregnant or breastfeeding) * Kidney ANGIOMYOLIPOMA 2 cm or greater on baseline MRI (a CT scan may be used for patients who cannot undergo MRI imaging) * No evidence of severe LAM (not on continuous oxygen) * Informed consent, including consent for submission of blood, urine and tissue samples as described in the appendix. * Adequate renal and liver function (eGFR of 30 or higher, SGOT, SGPT, TBili, Alk Phos all\<2x normal) * HCT\>27% * ANC \> 1500 and platelet count \>100,000 * Diagnosis of TSC or LAM (diagnosis of TSC using revised diagnostic criteria \[45\], diagnosis of LAM made by chest CT scan and reviewed by a pulmonologist). * Fertility/Reproductive issues: The effects of rapamycin on the developing fetus at the doses used in this study are unknown. For this reason, rapamycin should not be taken during pregnancy. Participants who are fertile must maintain adequate contraception while they are taking rapamycin and for twelve weeks after stopping the drug. Acceptable contraceptive measures include prior hysterectomy, oophorectomy or tubal ligation, complete abstinence, barrier methods which include both a cervical diaphragm and spermicidal jelly, and progestin based contraceptives. Pregnancy tests will be obtained at enrollment and during study visits at 8 weeks, 16 weeks, 24 weeks, 32 weeks, 40 weeks, and 52 weeks. * Note: Eligibility requirement of ECOG PS of 0 or 1 has been removed t…