CompletedPhase 2

Women's Isoflavone Soy Health (WISH) Trial

United States350 participantsStarted 2004-04-12

Plain-language summary

The purpose of this study is to determine whether soy supplementation can reduce hardening of the arteries and cognitive decline in postmenopausal women.

Who can participate

Age range30 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Postmenopausal, defined as no vaginal bleeding for at least 1 year and serum estradiol level lower than 20 pg/ml Exclusion Criteria: * Signs, symptoms or personal history of cardiovascular disease * Diabetes mellitus or fasting serum glucose of 126 mg/dL or greater * Fasting plasma triglyceride of 500 mg/dL or greater * Serum creatinine greater than 2.0 mg/dL * Uncontrolled hypertension * Untreated thyroid disease * Life expectancy less than 5 years * Current use of hormone replacement therapy (HRT) * Soy, nut, or related food allergies * More than 5 alcohol drinks per day or substance abuse

What they're measuring

Progression of Subclinical Atherosclerosis

Timeframe: Baseline x 2 and then every 6 months, up to 2.5 years

Trial details

NCT IDNCT00118846

SponsorUniversity of Southern California

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2009-03-19

Results submitted2023-03-17

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