CompletedNot Applicable

Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury

United States209 participantsStarted 2003-04

Plain-language summary

The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Recent blunt trauma * Of adult size if age is unknown * Pre-hospital systolic bloood pressure 90 mm Hg or less * Altered mental status * Transported directly to Harborview Medical Center from the injury event Exclusion Criteria: * Ongoing CPR * Transferred from outside hospitals * Pregnant or suspected pregnancy * Presence of injuries from penetrating trauma * Receiving more than 2000 cc of crystaloid prior to study fluid administration

What they're measuring

Adult respiratory distress syndrome symptoms (measured 28 days post-injury)

Trial details

NCT IDNCT00113685

SponsorUniversity of Washington

Sponsor typeOTHER

Study typeINTERVENTIONAL

View on ClinicalTrials.gov More Respiratory Distress Syndrome, Adult trials