Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or N… (NCT00084695) | Clinical Trial Compass
UnknownPhase 2
Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases
United States25 participantsStarted 2003-09
Plain-language summary
RATIONALE: Umbilical cord blood transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy.
PURPOSE: This phase II trial is studying how well umbilical cord blood works as a source of stem cells in treating patients with types of cancer as well as other diseases.
Who can participate
Age range21 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Diagnosis of malignant or non-malignant disease, including but not limited to any of the following:
* Acute myeloid leukemia or acute lymphoblastic leukemia (ALL) with resistant disease beyond first clinical remission (CR)
* ALL in first CR at high-risk because of 1 of the following factors:
* Hypoploidy
* Pseudodiploidy with translocations t(9;22), t(4;11), or t(8;14)
* Elevated WBC at diagnosis as follows:
* \> 100,000/mm\^3 for patients 6-12 months of age
* \> 50,000/mm\^3 for patients 10-20 years of age
* \> 20,000/mm\^3 for patients 21 years of age
* Burkitt's lymphoma/leukemia
* Chronic myelogenous leukemia in first chronic phase or beyond
* Juvenile myelomonocytic leukemia
* Advanced stage or relapsed lymphoma
* Advanced stage or relapsed solid tumors, including any of the following:
* Neuroblastoma
* Ewing's sarcoma
* Rhabdomyosarcoma
* Myelodysplastic syndromes, excluding patients with grade 3 or 4 myelofibrosis
* Familial erythrophagocytic histiocytosis
* Histiocytosis unresponsive to medical management
* Inborn errors of metabolism
* Langerhans cell histiocytosis unresponsive to medical management
* Immune deficiencies, including:
* Severe combined immune deficiency
* Wiskott-Aldrich
* Hemoglobinopathies, including sickle cell disease and thalassemia
* Severe aplastic anemia
* Fanconi's anemia
* Metabolic storage diseases
* Unrelated cord blood don…
What they're measuring
1
Impact of the use of umbilical cord blood as a source of hematopoietic stem cells
2
Comparison of the incidence of graft-vs-host disease with historical data
3
Comparison of the incidence of engraftment with historical data