A Study of Persons With Gout Who Do Not Respond to or Are Allergic to Conventional Therapy

Inclusion Criteria: Subjects to be included in the study are: * Outpatients of either gender, age 18 or older * Diagnosed with symptomatic gout refractory to conventional therapy or unable to tolerate conventional therapy (for example: having one or more tophi and/or having experienced a gout flare within the previous 6 months and/or having chronic, gouty arthritis) * Hyperuricemic: screening serum uric acid must be \>=8 mg/dL. * The patient must be willing and able to give informed consent and adhere to visit/protocol schedules (Consent must be given before any study procedures are performed) * Women of childbearing potential must have a negative serum pregnancy test and must use an approved birth control method during their participation in the protocol. Such methods include oral, injectable, or implantable contraceptives; IUDs and barrier contraceptives in combination with spermicide Exclusion Criteria: Subjects to be excluded are those for whom any of the following apply: * Unstable coronary artery disease or uncontrolled hypertension * History of end stage renal disease requiring dialysis * History of liver disease, as defined by baseline serum transaminase elevation \>3X the upper limit of normal in the absence of any other known cause * Organ transplant recipient requiring immunosuppressive therapy * Concurrent use of prednisone at a dose \>10 mg qd (or equivalent) at or within one week before dosing * Concurrent use of uric acid-lowering agents * Prior treatment …