CompletedNot Applicable

Prenatal Screening For Smith-Lemli-Opitz Syndrome

United States1,800 participantsStarted 2001-04

Plain-language summary

Smith-Lemli-Opitz Syndrome (SLOS) is a genetic condition that causes mental retardation and other birth defects. This study will evaluate a new prenatal screening test for SLOS.

Who can participate

SexFEMALE

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Inclusion Criteria * Pregnant, second trimester * Singleton pregnancy * Positive second trimester maternal serum screen for Smith-Lemli-Opitz Syndrome (using the Foundation for Blood Research screening algorithm ) Exclusion criteria: * Gestational age at time of serum collection outside the range accepted for Down Syndrome screening * Not pregnant * Twin/multiple pregnancy * Sample/clerical/assay error * Physician not participating in study

Trial details

NCT IDNCT00070850

SponsorEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sponsor typeNIH

Study typeOBSERVATIONAL

View on ClinicalTrials.gov More Smith-Lemli-Opitz Syndrome trials