Gemcitabine and Vinorelbine in Treating Young Patients With Recurrent or Refractory Hodgkin's Lym… (NCT00070304) | Clinical Trial Compass
CompletedPhase 2
Gemcitabine and Vinorelbine in Treating Young Patients With Recurrent or Refractory Hodgkin's Lymphoma
United States33 participantsStarted 2004-07
Plain-language summary
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and vinorelbine, use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving gemcitabine together with vinorelbine works in treating young patients with recurrent or refractory Hodgkin's lymphoma.
Who can participate
Age range30 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed Hodgkin's lymphoma\* with any of the following histologies:
* Not otherwise specified (NOS)
* Mixed cellularity NOS
* Lymphocytic depletion
* NOS
* Diffuse fibrosis
* Reticular
* Lymphocytic predominance
* NOS
* Diffuse
* Nodular
* Paragranuloma
* Granuloma
* Sarcoma
* Nodular sclerosis
* Cellular phase
* NOS
* Lymphocytic predominance
* Mixed cellularity
* Lymphocytic depletion NOTE: \*Disease metastatic to bone marrow with granulocytopenia and/or thrombocytopenia is allowed, but is not evaluable for hematological toxicity
* Measurable disease by clinical or radiographic criteria
* Relapsed or refractory to conventional therapy
* Received at least 2 prior cytotoxic chemotherapy regimens
* No stage IA or IIA nodal disease previously treated with any of the following:
* Radiotherapy only
* No more than 4 courses of prior chemotherapy
PATIENT CHARACTERISTICS:
Age
* 30 and under
Performance status
* Karnofsky 50-100% (over 16 years of age)
* Lansky 50-100% (16 and under) OR
* ECOG 0-2
Life expectancy
* At least 8 weeks
Hematopoietic
* See Disease Characteristics
* Absolute neutrophil count ≥ 750/mm\^3
* Platelet count ≥ 75,000/mm\^3 (transfusion independent, defined as ≥ 3 days since prior platelet transfusion)
Hepatic
* Bilirubin ≤ 1.5 times upper limit of normal (ULN)
* ALT ≤ 2.5 times ULN
Renal
* Creatinine clearance or radioisotope glomeru…